OrangerV1, Main, Exploration, bibRecord, 002018

Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks.

Identifieur interne : 002018 ( Main/Exploration ); précédent : 002017; suivant : 002019

Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks.

Auteurs : R. Séchaud [Suisse] ; C. Dutreix ; S. Balez ; F. Pommier ; T. Dumortier ; S. Morisson ; E. Brun

Source :

International journal of clinical pharmacology and therapeutics [ 0946-1965 ] ; 2008.

RBID : pubmed:18218291

English descriptors

KwdEn :
- Administration, Oral, Adult, Area Under Curve, Benzoates (blood), Benzoates (chemistry), Benzoates (pharmacokinetics), Beverages, Biological Availability, Chromatography, High Pressure Liquid, Citrus sinensis, Cross-Over Studies, Diarrhea (chemically induced), Drug Stability, Half-Life, Humans, Iron Chelating Agents (administration & dosage), Iron Chelating Agents (adverse effects), Iron Chelating Agents (pharmacokinetics), Male, Malus, Tablets, Tandem Mass Spectrometry, Triazoles (blood), Triazoles (chemistry), Triazoles (pharmacokinetics), Water (administration & dosage), Water (chemistry).
MESH :
- chemical , administration & dosage : Iron Chelating Agents, Water.
- chemical , adverse effects : Iron Chelating Agents.
- chemical , blood : Benzoates, Triazoles.
- chemical , chemistry : Benzoates, Triazoles, Water.
- chemical , pharmacokinetics : Benzoates, Iron Chelating Agents, Triazoles.
- chemically induced : Diarrhea.
- Administration, Oral, Adult, Area Under Curve, Beverages, Biological Availability, Chromatography, High Pressure Liquid, Citrus sinensis, Cross-Over Studies, Drug Stability, Half-Life, Humans, Male, Malus, Tablets, Tandem Mass Spectrometry.

Abstract

Deferasirox (ExjadeA, ICL670) is a new, once-daily oral iron chelator, recently approved as first-line therapy in the treatment of iron overload resulting from blood transfusions. In registration studies, deferasirox tablets were dispersed in non-carbonated water prior to administration. In routine clinical practice, however, patients may prefer to take the tablet dispersed in a flavored drink rather than with water.

PubMed: 18218291

Affiliations:

Suisse

Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>Novartis Pharma AG, Basel, Switzerland. romain.sechaud@novartis.com</nlm:affiliation>
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<author><name sortKey="Morisson, S" sort="Morisson, S" uniqKey="Morisson S" first="S" last="Morisson">S. Morisson</name>
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<author><name sortKey="Brun, E" sort="Brun, E" uniqKey="Brun E" first="E" last="Brun">E. Brun</name>
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<term>Benzoates (chemistry)</term>
<term>Benzoates (pharmacokinetics)</term>
<term>Beverages</term>
<term>Biological Availability</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Citrus sinensis</term>
<term>Cross-Over Studies</term>
<term>Diarrhea (chemically induced)</term>
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<term>Half-Life</term>
<term>Humans</term>
<term>Iron Chelating Agents (administration & dosage)</term>
<term>Iron Chelating Agents (adverse effects)</term>
<term>Iron Chelating Agents (pharmacokinetics)</term>
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<term>Drug Stability</term>
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<term>Malus</term>
<term>Tablets</term>
<term>Tandem Mass Spectrometry</term>
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<front><div type="abstract" xml:lang="en">Deferasirox (ExjadeA, ICL670) is a new, once-daily oral iron chelator, recently approved as first-line therapy in the treatment of iron overload resulting from blood transfusions. In registration studies, deferasirox tablets were dispersed in non-carbonated water prior to administration. In routine clinical practice, however, patients may prefer to take the tablet dispersed in a flavored drink rather than with water.</div>
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<name sortKey="Dumortier, T" sort="Dumortier, T" uniqKey="Dumortier T" first="T" last="Dumortier">T. Dumortier</name>
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Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks.

Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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